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INTRODUCTION

ABIM MOC Activity ID

11/18/2025 - Medical Grand Rounds: More Than A "Nuisance Arthritis": Gout's Effects on the Cardiovascular System

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Analyze the gout-arthritis paradigm
  • Assess gout-related comorbidities
  • Explain the biologic effects of uric acid on endothelial cells and white blood cells
  • Describe uric acid’s impact on the cardiovascular system

Suggested Additional Reading:

  • Firestein & Kelley’s Textbook of Rheumatology, Twelfth Edition, chapter 96: Etiology and Pathogenesis of Hyperuricemia and Gout. Elsevier 2025. 
  • Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020 Jul;16(7):380-390. doi: 10.1038/s41584-020-0441-1. PMID: 32541923.
  • Plotz B, Toprover M, Keenan RT, Pillinger MH. New perspectives on the NLRP3 inflammasome—colchicine and the suppression of inflammatory pathways in metabolic syndrome associated diseases. Explor Musculoskeletal Dis. 2025;3:1007104. https://doi.org/10.37349/emd.2025.1007104.

Authors:
Benjamin Plotz, MD — Assistant Professor of Medicine, Division of Rheumatology and Clicinal Immunology, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician (CME)

The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity.


Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.